Due to the preferable pharmacodynamics, Sevoflurane is the most favoured drug for the induction and maintenance of anaesthesia. Its low blood-gas partition coefficient helps to rapid alteration of the level of anaesthesia. CVS effects: → Mild ↓ cardiac contractility (dose-dependent, equal to isoflurane) → Mild ↓ SVR (dose-dependent, equal to Halothane) → Mild ↓ BP (dose-dependent, most least compared to others) → Minimal effect on HR → May cause prolongation of the QT interval → Not associated with coronary steal → Doesn't sensitize the myocardium → No effect on splanchnic blood flow Respiratory effects: → Non-irritant → Dose-dependent Tidal volume depression (less than Isoflurane, equal to Halothane) → ↑ RR (equal to Isoflurane, more than Halothane) → ↓ MV causing ↑ PaCO2 → Depression of hypoxic and hypercapnic ventilatory drive → Inhibition of hypoxic pulmonary vasoconstriction → Bronchial smooth muscle relaxation and reversal of bronchospasm CNS effects: → Effect on
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