Coagulation pathway (classical)


Extrinsic pathway -  

Tissue factor activates FVII.

Intrinsic pathway

Platelet acts as the stimulating factor, activating FXII, FXI, and FIX.

Both intrinsic and Extrinsic pathway follows the common pathway where FX is activated. 

Activated FX converts Prothrombin to Thrombin. 

Thrombin converts Fibrinogen to Fibrin, which in turn forms the stable clot.

Photo credit: Osmosis 


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